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M9490154.TXT
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1994-09-03
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Document 0154
DOCN M9490154
TI Cerebrospinal fluid p24 antigen levels and intrathecal immunoglobulin G
synthesis are associated with cognitive disease severity in HIV-1.
DT 9411
AU Singer EJ; Syndulko K; Fahy-Chandon BN; Shapshak P; Resnick L; Schmid P;
Conrad AJ; Tourtellotte WW; Neurology Service, Veterans Affairs Medical
Center West Los; Angeles, CA 90073.
SO AIDS. 1994 Feb;8(2):197-204. Unique Identifier : AIDSLINE MED/94318203
AB OBJECTIVE: To test the hypothesis that selected cerebrospinal fluid
(CSF) markers [intrathecal immunoglobulin G (IgG) synthesis rate,
oligoclonal IgG bands, and p24 antigen levels] are associated with the
presence and severity of clinical HIV-1 neurologic disease. DESIGN AND
METHODS: CSF and blood parameters from 142 HIV-seropositive subjects
from the baseline examination of a longitudinal study were measured and
analyzed in relationship with clinically derived cognitive impairment
groups (none, mild, moderate) and with other neurologic and clinical
classification groups. Subjects with opportunistic infections, lymphomas
or neurosyphilis were excluded. RESULTS: The mean intrathecal IgG
synthesis rate and mean CSF p24 antigen levels both differed
significantly among cognitive impairment groups; more impairment was
associated with a higher rate or level. Mean CSF p24 antigen levels were
significantly higher in HIV-1-seropositive subjects with any HIV-1
neurologic disease than in subjects without neurologic disease. In
contrast, there were no significant differences among seropositive
groups in any CSF parameter when stratified by systemic disease
classification (asymptomatic HIV-seropositives, AIDS-related complex, or
AIDS), independent of neurologic status. CONCLUSION: We conclude that
there may be a relationship between the severity of HIV cognitive
disease and increasing levels of intrathecal IgG synthesis and CSF p24
antigen levels.
DE Adult AIDS Dementia Complex/BLOOD/*CEREBROSPINAL FLUID/COMPLICATIONS/
IMMUNOLOGY Cerebrospinal Fluid Proteins/*ANALYSIS Comparative Study
Female Human HIV Core Protein p24/BLOOD/*CEREBROSPINAL FLUID
*HIV-1/IMMUNOLOGY IgG/BIOSYNTHESIS/*CEREBROSPINAL FLUID Male Middle
Age Risk Factors Severity of Illness Index Substance Abuse,
Intravenous/COMPLICATIONS Support, Non-U.S. Gov't Support, U.S. Gov't,
Non-P.H.S. Support, U.S. Gov't, P.H.S. Syphilis/COMPLICATIONS T4
Lymphocytes JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).